反应详情

To a solution of 75B (96 mg, 0.4 mmol) in 3 mL THF was added BH3 (2M in THF, 0.5 mL, 1 mmol). The solution was stirred at rt for 16 h. EtOAc (20 mL) was added, and the organic phase washed with 1M H3PO4, sat. NaHCO3 and brine, dried (Na2SO4), and concentrated. Purification via flash chromatography (0-30% EtOAc in hexanes) gives 75C (86 mg, 96%). MS (ESI) m/z 211.2(M−H2O)+.

1. washthe organic phase washed with 1M H3PO4, sat. NaHCO3 and brine
2. dry with materialdried (Na2SO4)
3. concentrationconcentrated
4. customPurification via flash chromatography (0-30% EtOAc in hexanes)