反应详情

An oven-dried Schlenk tube was charged with 2-bromo-4-tert-butyl-6-nitroanisole (500 mg, 1.74 mmol), 2-pyrrolidinone (158 μL, 2.09 mmol), Pd2(dba)3 (32 mg, 0.035 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (58 mg, 0.1 mmol) and Cs2CO3 (795 mg, 2.44 mmol). The tube was capped with a rubber septum, purged with argon and 1,4-dioxane (7 mL) was then added through the septum via a syringe. The tube was sealed with a teflon screwcap, and the reaction mixture was stirred at 100 C for 20 h. The reaction mixture was cooled to room temperature, diluted with EtOAc (100 mL), washed with water, brine and dried over anhydrous Na2SO4. The solvent was removed in vacuo, and crude product was purified by column chromatography (2:1 hexane-EtOAc) to give 1-(5-tert-butyl-2-methoxy-3-nitro-phenyl)-pyrrolidin-2-one (150 mg, 30%).

1. customThe tube was capped with a rubber septum
2. custompurged with argon and 1,4-dioxane (7 mL)
3. additionwas then added through the septum via a syringe
4. customThe tube was sealed with a teflon screwcap
5. additiondiluted with EtOAc (100 mL)
6. washwashed with water, brine
7. dry with materialdried over anhydrous Na2SO4
8. customThe solvent was removed in vacuo, and crude product
9. customwas purified by column chromatography (2:1 hexane-EtOAc)