HCID 10218354, compound → HCID 69000180, compound

HRID 735934Notes

Reaction equation

HRID 735934 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]#[C:16][C:17]2[CH:40]=[CH:39][C:20]([CH2:21][N:22]([C:34](=[O:38])[C:35]([OH:37])=[O:36])[CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=3)=[CH:19][CH:18]=2)=[CH:11][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]>CCOC(C)=O>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH2:16][C:17]2[CH:40]=[CH:39][C:20]([CH2:21][N:22]([C:34](=[O:38])[C:35]([OH:37])=[O:36])[CH2:23][C:24]3[CH:25]=[CH:26][C:27]([C:30]([F:32])([F:33])[F:31])=[CH:28][CH:29]=3)=[CH:19][CH:18]=2)=[CH:13][CH:14]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

3

Reactant 1

HCID 10218354HCID 10218354, compound

Product 1

HCID 69000180HCID 69000180, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The same procedure as employed in the preparation of Example 1 (step c) but using {(4-{[4-(heptyloxy)phenyl]ethynyl}benzyl)[4-(trifluoromethyl)benzyl]amino}(oxo)acetic acid in EtOAc gave the title compound as a colorless oil (54%). M−(LC/MS(ESI)): 554. HPLC (Condition A), Rt: 5.95 min (HPLC purity: 95.1%).

Workup

  1. customThe same procedure as employed in the preparation of Example 1 (step c)

Sources & evidence

ORD record
ord-0f2ed558afcf413e802a6bfd5b64785e
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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