HCID 67186027, compound → HCID 67189385, compound

HRID 735936Notes

Reaction equation

HRID 735936 reaction equation
[O:1]=[C:2]([N:6]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]#[C:26][C:27]2[CH:32]=[CH:31][C:30]([O:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])=[CH:29][CH:28]=2)=[CH:21][CH:20]=1)[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=1)[C:3]([OH:5])=[O:4]>CCOC(C)=O>[O:1]=[C:2]([N:6]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([O:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])=[CH:29][CH:28]=2)=[CH:21][CH:20]=1)[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:16])([F:17])[F:15])=[CH:10][CH:9]=1)[C:3]([OH:5])=[O:4]

Participants

3

Reactant 1

HCID 67186027HCID 67186027, compound

Product 1

HCID 67189385HCID 67189385, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The same procedure as employed in the preparation of Example 1 (step c) but using oxo{(4-{[4-(pentyloxy)phenyl]ethynyl}benzyl)[4-(trifluoromethyl)benzyl]amino}acetic acid in EtOAc gave the title compound as a yellow oil (49%). M−(LC/MS(ESI)): 526. HPLC (Condition A), Rt: 5.62 min (HPLC purity: 74.1%).

Workup

  1. customThe same procedure as employed in the preparation of Example 1 (step c)

Sources & evidence

ORD record
ord-b856c4e3bcf14b88a681a0452f310356
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

Loading…