HCID 67188790, compound → HCID 67187743, compound

HRID 735938Notes

Reaction equation

HRID 735938 reaction equation
[C:1]([C:4]([N:6]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]#[C:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35]([OH:37])=[O:36])=[CH:21][CH:20]=1)[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=1)=[O:5])([OH:3])=[O:2]>CCOC(C)=O>[C:1]([C:4]([N:6]([CH2:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35]([OH:37])=[O:36])=[CH:23][CH:24]=1)[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:15])([F:17])[F:16])=[CH:10][CH:9]=1)=[O:5])([OH:3])=[O:2]

Participants

3

Reactant 1

HCID 67188790HCID 67188790, compound

Product 1

HCID 67187743HCID 67187743, compoundYield 20%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The same procedure as employed in the preparation of Example 1 (step c) but using 11-[4-({(carboxycarbonyl)[4-(trifluoromethyl)benzyl]amino}methyl)phenyl]undec-10-ynoic acid in EtOAc gave the title compound as a colorless oil (20%). M−(LC/MS(ESI)): 520. HPLC (Condition A), Rt: 5.03 min (HPLC purity: 96.1%).

Workup

  1. customThe same procedure as employed in the preparation of Example 1 (step c)

Sources & evidence

ORD record
ord-b022ea2687554e32bca61d6c2020bfe6
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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