HCID 57847747, compound → HCID 69472192, compound

HRID 736011Notes

Reaction equation

HRID 736011 reaction equation
[C:1]([C:5]1[O:9][C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:7]([C:16]2[CH:21]=[CH:20][NH:19][C:18](=[O:22])[CH:17]=2)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>C1COCC1>[C:1]([C:5]1[O:9][C:8]2[C:7](=[C:16]3[C:17](=[C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][C:10]4=2)[C:18](=[O:22])[NH:19][CH:20]=[CH:21]3)[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 1

HCID 57847747HCID 57847747, compound

Product 1

HCID 69472192HCID 69472192, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 4-(5-tert-butyl-2-phenyl-3-furyl)pyridin-2(1H)-one (50 mg, 0.2 mmol) in THF (50 mL) was irradiated with a sun lamp for 5 h. The solution was then concentrated in vacuo and the product purified by flash chromatography using EtOAc-Pet. Spirit (80:20) as eluant, to separate the pure product as a cream solid (26 mg, 52%).

Workup

  1. concentrationThe solution was then concentrated in vacuo
  2. customthe product purified by flash chromatography
  3. customSpirit (80:20) as eluant, to separate the pure product as a cream solid (26 mg, 52%)

Sources & evidence

ORD record
ord-c2f57943da1a40f8875d5c0d20ca8946
Source dataset
uspto-grants-2009_09
Patent number
US07593820B2

Reaction notes

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