Ethyl Bromide → HCID 67291218, compound

HRID 736571Notes

Reaction equation

HRID 736571 reaction equation
[CH2:1]([Br:3])[CH3:2].[CH2:4]([C:6]1([CH3:30])[CH:11]([CH3:12])[CH:10]([OH:13])[CH2:9][C:8]([CH2:15][CH3:16])([CH3:14])[N:7]1[O:17][C:18]([CH3:29])([CH3:28])[C:19]([NH:21][CH2:22][CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])=[O:20])[CH3:5]>C(#N)C>[Br-:3].[CH2:4]([C:6]1([CH3:30])[CH:11]([CH3:12])[CH:10]([OH:13])[CH2:9][C:8]([CH2:15][CH3:16])([CH3:14])[N:7]1[O:17][C:18]([CH3:29])([CH3:28])[C:19]([NH:21][CH2:22][CH2:23][CH2:24][N+:25]([CH2:1][CH3:2])([CH3:27])[CH3:26])=[O:20])[CH3:5]

Participants

4

Reactant 2

HCID 6332Ethyl BromideHCID 57849395HCID 57849395, compound2×

Product 1

HCID 67291218HCID 67291218, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Ethylbromide (12 ml) is added to a solution of 2-(2,6-diethyl-4-hydroxy-2,3,6-trimethyl-piperidine-1-yloxy)-N-(3-dimethylamino-propyl)-2-methyl-propionamide (20.5 g, 0.053 mol, compound 110) in acetonitrile (35 ml). The mixture is stirred for 18 h at room temperature and is then evaporated to afford 26.63 g of the title compound as a colorless solid.

Workup

  1. customis then evaporated

Sources & evidence

ORD record
ord-7d0f311d024f4991b83fe0a6cfeb8b9a
Source dataset
uspto-grants-2009_09
Patent number
US07595359B2

Reaction notes

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