Hydrochloric Acid → HCID 68817491, compound

HRID 736743Notes

Reaction equation

C[O:2][C:3]([CH:5]1[CH:9]([NH:10][S:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][C:22]3[C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[N:25]=[C:24]([CH3:32])[CH:23]=3)=[CH:16][CH:15]=2)(=[O:13])=[O:12])[CH2:8][O:7][CH2:6]1)=[O:4].Cl>O1CCOCC1>[CH3:32][C:24]1[CH:23]=[C:22]([CH2:21][O:20][C:17]2[CH:18]=[CH:19][C:14]([S:11]([NH:10][CH:9]3[CH2:8][O:7][CH2:6][CH:5]3[C:3]([OH:4])=[O:2])(=[O:12])=[O:13])=[CH:15][CH:16]=2)[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[N:25]=1

Participants

Conditions

Temperature: 60 °C

Procedure

To a solution of 4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-tetrahydro-furan-3-carboxylic acid methyl ester (0.9 g, 1.97 mmol) in 1,4-dioxane (4 mL) was added concentrated HCl (4 mL). The reaction was heated to 60° C. for 19 h. The solvent was removed in vacuo to provide 4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonylamino]-tetrahydro-furan-3-carboxylic acid as a crude solid (0.6 g, 69%). MS: 443 (M+H)+

Workup

customThe solvent was removed in vacuo

Sources & evidence

ORD record: ord-2fa089aeb2af42e08d84fbc929198bf4
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595327B2

Reaction notes

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