Trifluoroacetic acid → HCID 68591763, compound

HRID 736947Notes

Reaction equation

HRID 736947 reaction equation
C(O)(C(F)(F)F)=O.[F:8][C:9]([F:32])([F:31])[C:10]([C:12]1[CH:17]=[CH:16][C:15]([N:18]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)=[CH:14][CH:13]=1)=[O:11]>C(Cl)Cl>[F:32][C:9]([F:8])([F:31])[C:10]([C:12]1[CH:13]=[CH:14][C:15]([N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)=[CH:16][CH:17]=1)=[O:11]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 692496391,1-Dimethylethyl 4-[4-(trifluoroacetyl)phenyl]-1-piperazinecarboxylate

Product 1

HCID 68591763HCID 68591763, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

2.0 mL TFA were added to a solution of 267 mg (0.75 mmol) tert. butyl 4-[4-(2,2,2-trifluoro-acetyl)-phenyl]-piperazin-1-carboxylate in 30 mL DCM cooled to 0° C. and the reaction mixture was stirred for 24 h, while warming up to RT. It was evaporated down i.vac.; the crude product was further reacted without purification.

Workup

  1. temperaturewhile warming up to RT
  2. customIt was evaporated down i.vac
  3. customthe crude product was further reacted without purification

Sources & evidence

ORD record
ord-d7e32d0443be4737918c03244e9d64ed
Source dataset
uspto-grants-2009_09
Patent number
US07595312B2

Reaction notes

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