huagongshe.com
HRID736983

反应详情

EQUATION

反应方程式

HRID 736983 的结构方程式

REACTANTS

反应物

2
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)c1ccc(S(=O)(=O)n2cc(C(C)C)c3ccccc32)cc1
HCID58975020

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)c1cn(S(=O)(=O)c2ccc(C(=O)O)cc2)c2ccccc12
HCID58975120

未命名化合物

收率 89.3%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：O=C([O-])O.[Na+]
溶剂HCID516892

Sodium Bicarbonate

CHNaO3

PROCEDURE

实验过程

Add five molar NaOH (1.5 mL 0.0075 mol) to a stirring solution of 4-(3-isopropyl-indole-1-sulfonyl)-benzoic acid methyl ester (0.230 g, 0.00061 mol) in THF (10.0 mL) at ambient temperature under N2. Stir the resulting mixture overnight Dilute with 5% NaHCO3 (75 mL) and extract with Et2O. Separate the aqueous layer and acidify with 37% HCl. Extract the resulting precipitate into EtOAc, wash with brine, dry (MgSO4), filter and evaporate giving 0.187 g of the title compound as an off white solid: Mass spectrum (m/e) (M−H) 342.0800; Found (M−H) 342.0802.

WORKUP

后处理

  1. extractionextract with Et2O
  2. customSeparate the aqueous layer
  3. extractionExtract the resulting precipitate into EtOAc
  4. washwash with brine
  5. dry with materialdry (MgSO4)
  6. filtrationfilter
  7. customevaporate