Hydrochloric Acid → HCID 58975133, compound

HRID 737019Notes

Reaction equation

HRID 737019 reaction equation
C[O:2][C:3](=[O:27])[C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15]([CH:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)=[N:14]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1.[OH-].[Na+].Cl>C1COCC1>[CH:22]1([C:15]2[C:16]3[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=3)[N:13]([S:10]([C:7]3[CH:8]=[CH:9][C:4]([C:3]([OH:27])=[O:2])=[CH:5][CH:6]=3)(=[O:11])=[O:12])[N:14]=2)[CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58975189HCID 58975189, compound

Product 1

HCID 58975133HCID 58975133, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Combine 4-(3-Cyclopentyl-indazole-1-sulfonyl)-benzoic acid methyl ester (2.045 g, 5.325 mmoles) in 50 ml of THF. Add 3 ml of 5 N NaOH and allow to stir for 15 hrs. Make the reaction acidic with HCl and extract into diethyl ether. Dry organic layer over MgSO4 and concentrate to isolate 1.243 g (Yield=63%) of the title compound: MS ES+ 369.47; MS ES− 369.46.

Workup

  1. extractionextract into diethyl ether
  2. concentrationDry organic layer over MgSO4 and concentrate

Sources & evidence

ORD record
ord-474e7d67e0804650afca0b174d994aec
Source dataset
uspto-grants-2009_09
Patent number
US07595339B2

Reaction notes

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