反应详情

Combine 4-(3-Phenyl-indole-1-sulfonyl)-benzoic acid (1.324 mmole) with N-hydroxy-succinamide (NHS− 1.457 mmoles), and EDC (1.324 mmoles) and stir in 20 ml dichloromethane for 15 hr. Condense the reaction to produce a solid. Isolate 0.613 g (yield=97.6%). React 1.05 mmole of residue with 4-aminomethyl-benzoic acid (1.05 mmole) in 3 ml dichloromethane for 15 hrs. Dilute reaction mixture and wash with 1 N HCl. Treat dichloromethane with MgSO4 and concentrate. Isolate a mixture of 4-(3-Phenyl-indole-1-sulfonyl)-benzoic acid and the title compound 0.258 g (48%): MS ES+ 5.10-77 MS ES− 509.21.

1. customCondense
2. customthe reaction
3. customto produce a solid
4. customIsolate 0.613 g (yield=97.6%)
5. additionDilute
6. customreaction mixture
7. washwash with 1 N HCl
8. concentrationTreat dichloromethane with MgSO4 and concentrate
9. customIsolate