Potassium Carbonate → HCID 57849544, compound

HRID 737092Notes

Reaction equation

HRID 737092 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[C:10]1([CH:16]2[CH2:20][CH2:19][NH:18][CH2:17]2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:18]2[CH2:19][CH2:20][CH:16]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:17]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 685274-Bromobenzyl bromideHCID 31467433-Phenylpyrrolidine

Product 1

HCID 57849544HCID 57849544, compoundYield 2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

5.632 g of 4-Bromobenzyl bromide and 2.211 of 3-Phenylpyrrolidine (Array) in 50 mL of acetonitrile were stirred at room temperature and 6.229 g of potassium carbonate was added. The reaction was stirred at room temperature overnight. The solution was filtered through Celite and concentrated in vacuo to afford a brown solid. Purification was done by flash chromatography to afford product. Wt: 33 mg, 2% yield, ES MS m/z 316/318

Workup

  1. filtrationThe solution was filtered through Celite
  2. concentrationconcentrated in vacuo
  3. customto afford a brown solid
  4. customPurification
  5. customto afford product

Sources & evidence

ORD record
ord-efe8d99b972144ca8cadf9d5ac6c6bd6
Source dataset
uspto-grants-2009_09
Patent number
US07595397B2

Reaction notes

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