p-Toluidine → 2-Pyridinamine, N-(4-methylphenyl)-

HRID 738463Notes

Reaction equation

HRID 738463 reaction equation
Brc1ccccn1.Cc1ccc(N)cc1>CN1CCCN2CCCN=C12.COc1ccc(OC)c([P](C(C)(C)C)(C(C)(C)C)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.CS(C)=O.c1ccc(-c2ncno2)cc1>Cc1ccc(Nc2ccccn2)cc1

Participants

7

Reactant 2

HCID 7813p-ToluidineHCID 79732-Bromopyridine

Product 1

HCID 27864192-Pyridinamine, N-(4-methylphenyl)-Yield 71.251%

Reagents, catalysts & solvents 4

HCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneReagentHCID 4616330HCID 4616330, compoundReagentHCID 178492620HCID 178492620, compoundCatalystHCID 679Dimethyl SulfoxideSolvent5×

Conditions

Temperature
60 °C

Procedure

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-0646dd5b4d5246e3ba35bd986556ffb9
Source dataset
Ahneman

Reaction notes

Loading…