反应详情

A solution of BH3.Me2S in THF (2 M, 7.75 mL, 15.5 mmol) was added dropwise to a suspension of 6-nitro-4H-benzo[1,4]oxazin-3-one (0.6 g, 3.1 mmol) in THF (10 mL). The mixture was stirred at room temperature overnight. The reaction was quenched with MeOH (5 mL) at 0° C. and then water (20 mL) was added. The mixture was extracted with Et2O and the combined organic layers were washed with brine, dried over Na2SO4 and concentrated to give 6-nitro-3,4-dihydro-2H-benzo[1,4]oxazine as a red solid (0.5 g, 89%), which was used without further purification.

1. customThe reaction was quenched with MeOH (5 mL) at 0° C.
2. additionwater (20 mL) was added
3. extractionThe mixture was extracted with Et2O
4. washthe combined organic layers were washed with brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated