Hydrochloric Acid → HCID 12786839, compound

To a solution of 1,1,2 trichloro-2,3,3-trifluorocyclobutane (55.5 g) in 100 ml of anhydrous ether, triethylamine (40 ml) was added dropwise over 30 min at room temperature, and the mixture was stirred overnight at ambient temperature. The mixture was then stirred with 120 ml H2O and 7.5 ml of concentrated HCl. The ether layer was washed with H2O (100 ml), brine (100 ml), dried over anhydrous MgSO4, and evaporated in vacuo. The residue was distilled fractionally at atmospheric pressure from 64°-68° C. to yield 36 g (79%) of a colorless liquid as pure product.

1. washThe ether layer was washed with H2O (100 ml), brine (100 ml)
2. dry with materialdried over anhydrous MgSO4
3. customevaporated in vacuo
4. distillationThe residue was distilled fractionally at atmospheric pressure from 64°-68° C.

ORD record

ord-da07e9902e4b441581eb1ef3e56f3769

Source dataset

uspto-grants-1996_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05552409