反应详情

温度

5 °C

A 4-neck flask (1 L) was charged with 2-acetoxymethyl-5-(benzothiazol-2-yl)-1-(tetrahydropyran-4-yl)benzimidazole (see Working Example 7-2) (5.00 g, 12.27 mmol), and methanol (253 mL), and an aqueous lithium hydroxide solution (1.0 M, 61 mL) was added at room temperature. After stirring under these conditions for 2 h, this was cooled in ice (0 to 10° C.) and dilute hydrochloric acid was added to the liquid to give an approximate pH of 5. The precipitated crystals were filtered off, washed with distilled water, and then dried under reduced pressure with heating to yield the title compound (4.28 g, 95.4% yield) as a greenish-white powder.

1. customto give an approximate pH of 5
2. filtrationThe precipitated crystals were filtered off
3. washwashed with distilled water
4. customdried under reduced pressure
5. temperaturewith heating