反应详情

2.50 g (7.97 mmol) of 3-(5-(S)-3-aminopropyl-2,4-dioxoimidazolidin-3-yl)benzoic acid and 2.15 g (7.97 mmol) of 1-acetoxyethyl p-nitrophenyl carbonate are dissolved in 50 ml of DMF, treated with 3.33 ml (24 mmol) of triethylamine and stirred at room temperature for 3 d. The mixture is concentrated in vacuo and the residue is chromatographed on silica gel (dichloromethane/methanol/glacial acetic acid).

1. concentrationThe mixture is concentrated in vacuo
2. customthe residue is chromatographed on silica gel (dichloromethane/methanol/glacial acetic acid)