Triethylamine → HCID 19069747, compound

HRID 742245Notes

Reaction equation

HRID 742245 reaction equation
[CH2:1]([NH:3][CH2:4][C:5]([OH:7])=O)[CH3:2].[CH2:8]([N:12]=[C:13]=[S:14])[CH:9]([CH3:11])[CH3:10].C(N(CC)CC)C>C(Cl)Cl>[CH2:1]([N:3]1[CH2:4][C:5](=[O:7])[N:12]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:13]1=[S:14])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 68960Isobutyl isothiocyanateHCID 316542N-Ethylglycine

Product 1

HCID 19069747HCID 19069747, compoundYield 23.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared by the procedure described in Example 19 using 9.2 g of N-ethyl glycine, 5.7 g of isobutyl-isothiocyanate, 10.1 g of triethylamine, and 150 mL of methylene chloride. Purification was achieved by flash chromatography on silica gel (methylene chloride). Title compound (2.3 g) was obtained as an oil. Anal. Calcd. for. C9H16N2O S: C, 53.97; H, 8.05; N, 13.99. Found: C, 54.01; H, 8.21; N, 14.00) Mass spectrum (El, M.+) m/z 200.

Workup

  1. customThe title compound was prepared by the procedure
  2. customPurification

Sources & evidence

ORD record
ord-a3fa83712cb241319a6700c6116e7f49
Source dataset
uspto-grants-1996_09
Patent number
US05554607

Reaction notes

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