Triethylamine → HCID 19425379, compound

HRID 742246Notes

Reaction equation

HRID 742246 reaction equation
[CH2:1]([NH:3][CH2:4][C:5]([OH:7])=O)[CH3:2].[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]=[C:16]=[S:17].C(N(CC)CC)C>C(Cl)Cl>[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[C:5](=[O:7])[CH2:4][N:3]([CH2:1][CH3:2])[C:16]1=[S:17]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1231711-Chloro-2-isothiocyanatobenzeneHCID 316542N-Ethylglycine

Product 1

HCID 19425379HCID 19425379, compoundYield 30.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared by the; procedure described in Example 19 using 9.2 g of N-ethyl glycine, 8.48 g of 2-chlorophenyl-isothiocyanate, 10.1 g of triethylamine, and 150 mL of methylene chloride. Purification was achieved through crystallization from ethanol. Title compound (3.85 g) was obtained as an orange solid, m.p. 142°-145° C. Anal. Calcd. for. C11H11Cl N2O S: C, 51.87; H, 4.35; N, 11.00. Found: C, 51.96; H, 4.26; N, 10.97. Mass spectrum (EI, M.+) m/z 254.

Workup

  1. customThe title compound was prepared by the
  2. customPurification
  3. customwas achieved through crystallization from ethanol

Sources & evidence

ORD record
ord-c79c43918b0b433289b3f98e6000e0b7
Source dataset
uspto-grants-1996_09
Patent number
US05554607

Reaction notes

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