Hydrogen Bromide → 1-(Bromomethyl)-4-(trifluoromethyl)benzene

HRID 742463Notes

Reaction equation

HRID 742463 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH2:7]O)=[CH:5][CH:4]=1.O.[BrH:14]>>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][C:6]([CH2:7][Br:14])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 962WaterHCID 676844-(Trifluoromethyl)benzenemethanol

Product 1

HCID 1230621-(Bromomethyl)-4-(trifluoromethyl)benzene

Procedure

A mixture of 5.5 g of p-trifluoromethyl-benzyl alcohol in 50 mL of 48% HBr was heated on a steam-bath for 6 h with stirring, and cooled. Water (100 mL) was added to the above mixture, and the aqueous layer was extracted with ether, and the organic layer was concentrated in vacuo to afford 4.8 g of p-trifluoromethyl-benzyl bromide.

Workup

  1. temperaturewas heated on a steam-bath for 6 h
  2. temperaturecooled
  3. extractionthe aqueous layer was extracted with ether
  4. concentrationthe organic layer was concentrated in vacuo

Sources & evidence

ORD record
ord-4eb45ddb9be34dabbad329cb9fd7f051
Source dataset
uspto-grants-1996_09
Patent number
US05554620

Reaction notes

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