反应详情

A mixture of 1 g (8.26 mmol) of 4-methylpyridine-2-carboxaldehyde, and 1.41 g (8.3 mmol) of benzyl bromide in 10 mL of sulfolane was stirred and heated on a steam-bath overnight. The resulting mixture was triturated (repeatedly) with ethyl acetate and the solvent was decanted to isolate a dark gum. This residue was dissolved in water, and washed with ether, and the aqueous solution was concentrated in vacuo to afford 1-benzyl-4-methyl-2-formyl-pyridinium bromide, which was used without additional purification.

1. temperatureheated on a steam-bath overnight
2. customThe resulting mixture was triturated (repeatedly) with ethyl acetate
3. customthe solvent was decanted
4. customto isolate a dark gum
5. washwashed with ether
6. concentrationthe aqueous solution was concentrated in vacuo