反应详情

1-(2-Aminoethyl)-5-(benzoxazol-2-yl)-2-methylbenzimidazole hydrochloride (see Working Example 56) (0.20 g, 0.6 mmol), methyl isothiocyanate (0.17 g, 0.6 mmol), triethylamine (0.13 g, 13 mmol) and THF (2 mL) were added together, and stirred for 1 hour at room temperature. After cooling, chloroform and water were added and extraction was carried out. After the organic layer obtained was dried over anhydrous sodium sulfate, it was filtered and concentrated. The solid obtained was separated by filtration and dried to yield the title compound (0.08 g, 40% yield) as white crystals.

1. temperatureAfter cooling
2. extractionextraction
3. customAfter the organic layer obtained
4. dry with materialwas dried over anhydrous sodium sulfate, it
5. filtrationwas filtered
6. concentrationconcentrated
7. customThe solid obtained
8. customwas separated by filtration
9. customdried