HCID 19423444, compound → HCID 19027729, compound

HRID 742980Notes

Reaction equation

HRID 742980 reaction equation
C([NH:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][C:9](=[O:31])[N:10]2[CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[CH:25]=2)[CH2:20][CH2:19]1)(=O)C>Cl>[ClH:30].[ClH:30].[NH2:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][C:9](=[O:31])[N:10]2[CH2:15][CH2:16][CH2:17][N:18]1[CH2:19][CH2:20][N:21]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[CH:25]=2)[CH2:22][CH2:23]1

Participants

3

Reactant 1

HCID 19423444HCID 19423444, compound

Product 1

HCID 19027729HCID 19027729, compoundYield 168.2%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

5-Acetylamino-1-{3-[4-(3-chlorophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril (800 mg) was dissolved in 20 ml of 6 N hydrochloric acid, and the mixture was heated under reflux for 1 hour. The reaction mixture was concentrated under reduced pressure and the residue was recrystallized from ethanol to give 480 mg of 5-amino-1-{3-[4-(3-chlorophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril dihydrochloride as a white powder.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1 hour
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-ad3b480fff13480c941b0c5c1944133d
Source dataset
uspto-grants-1996_09
Patent number
US05556857

Reaction notes

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