Hydrochloric Acid → N,N-Diethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine hydrochloride

HRID 743177노트

반응식

HRID 743177 반응식
[ClH:1].[CH2:2]([N:4]([CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][CH2:17][CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:5][CH3:6])[CH3:3]>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[CH2:2]([N:4]([CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][CH2:17][CH2:18][CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[CH2:5][CH3:6])[CH3:3]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 19423947N,N-Diethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine

생성물 1

HCID 19423946N,N-Diethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine hydrochloride수율 40%

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 312751,4-Dioxane용매

실험 절차

0.59 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 490 mg of N,N-diethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine [prepared as described in step (a) above] in 5 ml of ethyl acetate, and the crystals which precipitated were collected by filtration, washed with ethyl acetate and dried in vacuo, to give 216 mg (yield 40%) of the title compound as colorless crystals, melting at 135°-138° C.

후처리

  1. customthe crystals which precipitated
  2. filtrationwere collected by filtration
  3. washwashed with ethyl acetate
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-462112e3191842568b7eb8713aceac69
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556864

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