Hydrochloric Acid → 4-Methyl-2-[2-(4-phenylbutyl)phenoxymethyl]morpholine hydrochloride

HRID 743184Notes

Reaction equation

HRID 743184 reaction equation
[ClH:1].[CH3:2][N:3]1[CH2:8][CH2:7][O:6][CH:5]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:17][CH2:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:4]1>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[CH3:2][N:3]1[CH2:8][CH2:7][O:6][CH:5]([CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:17][CH2:18][CH2:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:4]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 108095004-Methyl-2-[2-(4-phenylbutyl)phenoxymethyl]morpholine

Product 1

HCID 574976064-Methyl-2-[2-(4-phenylbutyl)phenoxymethyl]morpholine hydrochlorideYield 86%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

0.26 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 183 mg of 4-methyl-2-[2-(4-phenylbutyl)phenoxymethyl]morpholine [prepared as described in step (a) above] in 5 ml of ethyl acetate, and the resulting mixture was allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 175 mg (yield 86%) of the title compound as colorless needles, melting at 135°-136° C.

Workup

  1. customto stand at room temperature
  2. customThe crystals which precipitated
  3. filtrationwere collected by filtration
  4. customdried in vacuo

Sources & evidence

ORD record
ord-cb16c9d2804747688162bf4dbe02a497
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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