Hydrochloric Acid → HCID 19423913, compound

HRID 743187Notes

Reaction equation

HRID 743187 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:26]=[CH:25][CH:24]=[CH:23][C:14]=1[O:15][CH2:16][CH:17]([OH:22])[CH2:18][N:19]([CH3:21])[CH3:20])#[N:2].C(OCC)(=O)C.[ClH:33]>O1CCOCC1>[ClH:33].[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:26]=[CH:25][CH:24]=[CH:23][C:14]=1[O:15][CH2:16][CH:17]([OH:22])[CH2:18][N:19]([CH3:20])[CH3:21])#[N:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 15389031HCID 15389031, compound

Product 1

HCID 19423913HCID 19423913, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Following a procedure similar to that described in Example 1(c), a solution of 267 mg of 1-{2-[4-(2-cyanophenyl) butyl]phenoxy}-3-dimethylamino-2-propanol [prepared as described in step (b) above] in a suitable amount of ethyl acetate was treated with 0.5 ml of a 4N solution of hydrogen chloride in dioxane. The solvent was then removed by distillation under reduced pressure, and the residue was dried in vacuo, to give 294 mg of the title compound as a colorless oil.

Workup

  1. customThe solvent was then removed by distillation under reduced pressure
  2. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-0774797685144f14b20451960691177a
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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