Hydrochloric Acid → 1-{2-[4-(3,5-Dimethoxyphenyl)butyl]phenoxy}-3-dimethylamino-2-propanol hydrochloride

HRID 743191Notes

Reaction equation

HRID 743191 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:12][CH2:13][CH2:14][CH2:15][C:16]2[CH:29]=[CH:28][CH:27]=[CH:26][C:17]=2[O:18][CH2:19][CH:20]([OH:25])[CH2:21][N:22]([CH3:24])[CH3:23])[CH:7]=[C:8]([O:10][CH3:11])[CH:9]=1>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[CH3:11][O:10][C:8]1[CH:7]=[C:6]([CH2:12][CH2:13][CH2:14][CH2:15][C:16]2[CH:29]=[CH:28][CH:27]=[CH:26][C:17]=2[O:18][CH2:19][CH:20]([OH:25])[CH2:21][N:22]([CH3:23])[CH3:24])[CH:5]=[C:4]([O:3][CH3:2])[CH:9]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 106222221-{2-[4-(3,5-Dimethoxyphenyl)butyl]phenoxy}-3-dimethylamino-2-propanol

Product 1

HCID 574976071-{2-[4-(3,5-Dimethoxyphenyl)butyl]phenoxy}-3-dimethylamino-2-propanol hydrochloride

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

Following a procedure similar to that described in Example 1(c), 2 ml of a 4N solution of hydrogen chloride in dioxane were added to a solution of 0.29 g of 1-{2-[4-(3,5-dimethoxyphenyl)butyl]phenoxy}-3-dimethylamino-2-propanol [prepared as described in step (b) above] in ethyl acetate. The solvent was then removed by distillation under reduced pressure, and the resulting residue was dried in vacuo, to give 320 mg of the title compound as a colorless oil.

Workup

  1. customThe solvent was then removed by distillation under reduced pressure
  2. customthe resulting residue was dried in vacuo

Sources & evidence

ORD record
ord-683899be1c9543e79adbf7951d68fef5
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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