Hydrochloric Acid → 3-Dimethylamino-1-{2-[4-(2-methoxyphenyl)butyl]phenoxy}-2-propanol hydrochloride

HRID 743198Notes

Reaction equation

HRID 743198 reaction equation
[CH3:1][N:2]([CH3:26])[CH2:3][CH:4]([OH:25])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][CH3:24].[ClH:27]>C(OCC)(=O)C.O1CCOCC1>[ClH:27].[CH3:26][N:2]([CH3:1])[CH2:3][CH:4]([OH:25])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][CH3:24]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 106206163-Dimethylamino-1-{2-[4-(2-methoxyphenyl)butyl]phenoxy}-2-propanol

Product 1

HCID 574976093-Dimethylamino-1-{2-[4-(2-methoxyphenyl)butyl]phenoxy}-2-propanol hydrochloride

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

Following a procedure similar to that described in Example 1(c), a solution of 250 mg of 3-dimethylamino-1-{2-[4-(2-methoxyphenyl)butyl]phenoxy}-2-propanol [prepared as described in step (b) above] in 5 ml of ethyl acetate was treated with 0.35 ml of a 4N solution of hydrogen chloride in dioxane. The solvent was then removed by distillation under reduced pressure, and the residue was dried in vacuo, to give 275 mg (a quantitative yield) of the title compound as a colorless oil.

Workup

  1. customThe solvent was then removed by distillation under reduced pressure
  2. customthe residue was dried in vacuo

Sources & evidence

ORD record
ord-d533a8185f5e4f69b42b322b88f85b0a
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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