Epibromohydrin → HCID 19423887, compound

HRID 743199Notes

Reaction equation

HRID 743199 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[OH:20])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[CH3:21][C:22](C)([O-:24])[CH3:23].[K+].C(C1OC1)Br>CC(N(C)C)=O>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH2:21][CH:22]2[CH2:23][O:24]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 18430EpibromohydrinHCID 19423843HCID 19423843, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 19423887HCID 19423887, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

Following a procedure similar to that described in Example 1(a), 3.04 g of 2-[4-(4-isopropylphenyl)butyl]phenol (prepared as described in Preparation 8), 1.27 g of potassium t-butoxide and 3.11 g of epibromohydrin were reacted in 60 ml of dimethylacetamide. The crude product, extracted as described in Example 1(a), was purified as described in Example 1(a), to give 3.23 g (yield 88%) of the title compound as a colorless oil.

Workup

  1. extractionThe crude product, extracted
  2. customwas purified

Sources & evidence

ORD record
ord-66315b81c51b4d69bc09000132058052
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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