Hydrochloric Acid → HCID 19423882, compound

HRID 743201Notes

Reaction equation

HRID 743201 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:28])[CH2:4][CH:5]([OH:27])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH:24]([CH3:26])[CH3:25])=[CH:20][CH:19]=1>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[CH3:28][N:3]([CH3:2])[CH2:4][CH:5]([OH:27])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH:24]([CH3:25])[CH3:26])=[CH:20][CH:19]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19423868HCID 19423868, compound

Product 1

HCID 19423882HCID 19423882, compoundYield 82%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

Following a procedure similar to that described in Example 1(c), 1 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 703 mg of 3-dimethylamino-1-{2-[4-(4-isopropylphenyl)butYl]phenoxy}-2-propanol [prepared as described in step (b) above] in 7 ml of ethyl acetate. The resulting mixture was concentrated by evaporation under reduced pressure, and the resulting oily residue was dissolved in ethyl acetate and allowed to stand. The crystals which precipitated were collected by filtration and dried in vacuo, to give 665 mg (yield 82%) of the title compound as colorless crystals, melting at 76°-77° C.

Workup

  1. concentrationThe resulting mixture was concentrated by evaporation under reduced pressure
  2. dissolutionthe resulting oily residue was dissolved in ethyl acetate
  3. customThe crystals which precipitated
  4. filtrationwere collected by filtration
  5. customdried in vacuo

Sources & evidence

ORD record
ord-ecb235da1d61416485e2788f9a666abd
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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