Hydrochloric Acid → 1-[2-(4-Phenylbutyl)phenoxy]-3-(4-phenylpiperazin-1-yl)-2-propanol dihydrochloride

HRID 743205Notes

Reaction equation

HRID 743205 reaction equation
[ClH:1].[C:2]1([CH2:8][CH2:9][CH2:10][CH2:11][C:12]2[CH:34]=[CH:33][CH:32]=[CH:31][C:13]=2[O:14][CH2:15][CH:16]([OH:30])[CH2:17][N:18]2[CH2:23][CH2:22][N:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:20][CH2:19]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[ClH:1].[C:2]1([CH2:8][CH2:9][CH2:10][CH2:11][C:12]2[CH:34]=[CH:33][CH:32]=[CH:31][C:13]=2[O:14][CH2:15][CH:16]([OH:30])[CH2:17][N:18]2[CH2:23][CH2:22][N:21]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH2:20][CH2:19]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 98712401-[2-(4-Phenylbutyl)phenoxy]-3-(4-phenylpiperazin-1-yl)-2-propanol

Product 1

HCID 98712391-[2-(4-Phenylbutyl)phenoxy]-3-(4-phenylpiperazin-1-yl)-2-propanol dihydrochlorideYield 92%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

1.55 ml of a 4N solution of hydrogen chloride in dioxane were added to a solution of 920 mg of 1-[2-(4-phenylbutyl)phenoxy]-3-(4-phenylpiperazin-1-yl)-2-propanol [prepared as described in step (a) above] in 20 ml of ethyl acetate, and the resulting mixture was allowed to stand at room temperature for 1 hour. The crystals which precipitated were collected by filtration and dried in vacuo, to give 990 mg (yield 92%) of the title compound as a colorless powder, melting at 102°-104° C.

Workup

  1. customThe crystals which precipitated
  2. filtrationwere collected by filtration
  3. customdried in vacuo

Sources & evidence

ORD record
ord-b6b79bb617d148d9a9727c14f339acfa
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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