Epibromohydrin → HCID 19423936, compound

HRID 743210Notes

Reaction equation

HRID 743210 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[OH:18])=[CH:4][CH:3]=1.[CH3:19][C:20](C)([O-:22])[CH3:21].[K+].C(C1OC1)Br>CC(N(C)C)=O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH2:19][CH:20]2[CH2:21][O:22]2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 18430EpibromohydrinHCID 19423897HCID 19423897, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 19423936HCID 19423936, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

Following a procedure similar to that described in Example 1(a), 0.70 g of 2-[4-(4-methylphenyl)butyl]phenol (prepared as described in Preparation 6), 0.33 g of potassium t-butoxide and 0.8 g of epibromohydrin were reacted in 40 ml of dimethylacetamide. The crude product, extracted as described in Example 1(a), was purified as described in Example 1(a), to give 0.63 g (yield 73%) of the title compound as a colorless oil.

Workup

  1. extractionThe crude product, extracted
  2. customwas purified

Sources & evidence

ORD record
ord-4d55730a5d2c43dc898d34d2bb972c5a
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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