Hydrochloric Acid → HCID 19423937, compound

HRID 743212Notes

Reaction equation

HRID 743212 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:26])[CH2:4][CH:5]([OH:25])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=1.C(OCC)(=O)C>O1CCOCC1>[ClH:1].[CH3:26][N:3]([CH3:2])[CH2:4][CH:5]([OH:25])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 19423938HCID 19423938, compound

Product 1

HCID 19423937HCID 19423937, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

0.95 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 640 mg of 3-dimethylamino-1-{2-[4-(4-methylphenyl)butyl]phenoxy}-2-propanol [prepared as described in step (b) above] in a suitable amount of ethyl acetate, and the resulting solution was concentrated by evaporation under reduced pressure. The resulting residue was then dried in vacuo, to give 708 mg (a quantitative yield) of the title compound as a colorless oil.

Workup

  1. concentrationthe resulting solution was concentrated by evaporation under reduced pressure
  2. customThe resulting residue was then dried in vacuo

Sources & evidence

ORD record
ord-e211b42920244397925f5db1d2c6aee7
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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