Dimethylamine → HCID 54340814, compound

HRID 743214Notes

Reaction equation

HRID 743214 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH2:15][CH2:16][CH:17]=[CH:18][C:19]1[CH:29]=[CH:28][CH:27]=[CH:26][C:20]=1[O:21][CH2:22][CH:23]1[CH2:25][O:24]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:30][NH:31][CH3:32]>O1CCCC1>[CH3:30][N:31]([CH3:32])[CH2:25][CH:23]([OH:24])[CH2:22][O:21][C:20]1[CH:26]=[CH:27][CH:28]=[CH:29][C:19]=1[CH:18]=[CH:17][CH2:16][CH2:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 540152802-{2-[4-(2-Benzyloxyphenyl)-1-buten-1-yl]phenoxymethyl}oxirane

Product 1

HCID 54340814HCID 54340814, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 1(b), a solution of 328 mg of 2-{2-[4-(2-benzyloxyphenyl)-1-buten-1-yl]phenoxymethyl}oxirane [prepared as described in step (a) above] dissolved in 5 ml of tetrahydrofuran was treated with 3 ml of 50% by volume aqueous dimethylamine. The crude product was purified as described in Example 1(b), to give 3-dimethylamino-1-{2-[4-(2-benzyloxyphenyl)-1-buten-1-yl]phenoxy}-2-propanol as a colorless oil.

Workup

  1. customThe crude product was purified

Sources & evidence

ORD record
ord-64a97942b93547c6885641021e15940f
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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