Dimethylamine → HCID 19423939, compound

HRID 743217Notes

Reaction equation

HRID 743217 reaction equation
[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=2[O:17][CH2:18][CH:19]2[CH2:21][O:20]2)[CH:8]=[CH:9][CH:10]=1.[CH3:26][NH:27][CH3:28]>O1CCCC1>[CH3:26][N:27]([CH3:28])[CH2:21][CH:19]([OH:20])[CH2:18][O:17][C:16]1[CH:22]=[CH:23][CH:24]=[CH:25][C:15]=1[CH2:14][CH2:13][CH2:12][CH2:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([O:4][CH2:3][O:2][CH3:1])[CH:6]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 19424026HCID 19424026, compound

Product 1

HCID 19423939HCID 19423939, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Example 1(b), 1.40 g of 2-{2-[4-(3-methoxymethoxyphenyl)butyl]phenoxymethyl]oxirane [prepared as described in step (a) above] dissolved in 14 ml of tetrahydrofuran were treated with 2.8 ml of 50% by volume aqueous dimethylamine. The crude product was purified as described in Example 1(b), to give 1.51 g (yield 95%) of the title compound as a colorless oil.

Workup

  1. customThe crude product was purified

Sources & evidence

ORD record
ord-03fcdf82af974687b4e15f6e71501765
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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