反应详情

Following a procedure similar to that described in Example 1(c), 450 mg of 1-methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}piperidine [prepared as described in step (a) above] dissolved in 5 ml of ethyl acetate were converted to the hydrdochloride by treating it with 0.4 ml of a 4N solution of hydrogen chloride in dioxane. The reaction mixture was then concentrated by evaporation under reduced pressure and dried in vacuo, to give 496 mg of the title compound as a colorless oil.

1. concentrationThe reaction mixture was then concentrated by evaporation under reduced pressure
2. customdried in vacuo