Hydrochloric Acid → 1-Methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}piperidine hydrochloride

HRID 743240Notes

Reaction equation

HRID 743240 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[ClH:27]>C(OCC)(=O)C.O1CCOCC1>[ClH:27].[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 105723171-Methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}piperidine

Product 1

HCID 574976141-Methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}piperidine hydrochloride

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

Following a procedure similar to that described in Example 1(c), 450 mg of 1-methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}piperidine [prepared as described in step (a) above] dissolved in 5 ml of ethyl acetate were converted to the hydrdochloride by treating it with 0.4 ml of a 4N solution of hydrogen chloride in dioxane. The reaction mixture was then concentrated by evaporation under reduced pressure and dried in vacuo, to give 496 mg of the title compound as a colorless oil.

Workup

  1. concentrationThe reaction mixture was then concentrated by evaporation under reduced pressure
  2. customdried in vacuo

Sources & evidence

ORD record
ord-f5a6f365467b4f26a2b48a2a3246e0b3
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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