Hydrochloric Acid → 2-(2-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}-ethyl]-1-methylpyrrolidine hydrochloride

HRID 743245Notes

Reaction equation

HRID 743245 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]2[CH:26]=[CH:25][CH:24]=[CH:23][C:13]=2[O:14][CH2:15][CH2:16][CH:17]2[CH2:21][CH2:20][CH2:19][N:18]2[CH3:22])[CH:7]=[CH:8][CH:9]=1>C(OCC)(=O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]2[CH:26]=[CH:25][CH:24]=[CH:23][C:13]=2[O:14][CH2:15][CH2:16][CH:17]2[CH2:21][CH2:20][CH2:19][N:18]2[CH3:22])[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 158968632-(2-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}ethyl)-1-methylpyrrolidine

Product 1

HCID 194238542-(2-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}-ethyl]-1-methylpyrrolidine hydrochlorideYield 81%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

11 ml of a 4N solution of hydrogen chloride in ethyl acetate were added, whilst ice-cooling, to a solution of 14.5 g of 2-(2-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}ethyl)-1-methylpyrrolidine [prepared as described in step (a) above] in 100 ml of ethyl acetate, and the resulting mixture was allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 3.0 g (yield 81%) of the title compound as colorless crystals, melting at 109°-110° C.

Workup

  1. customto stand at room temperature
  2. customThe crystals which precipitated
  3. filtrationwere collected by filtration
  4. customdried in vacuo

Sources & evidence

ORD record
ord-a3dbe47219514299ab12933832da528b
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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