Hydrochloric Acid → 4-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}-1-methylpiperidine hydrochloride

HRID 743251Notes

Reaction equation

HRID 743251 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]2[CH:25]=[CH:24][CH:23]=[CH:22][C:13]=2[O:14][CH:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)[CH:7]=[CH:8][CH:9]=1>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]2[CH:25]=[CH:24][CH:23]=[CH:22][C:13]=2[O:14][CH:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)[CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 105706074-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}-1-methylpiperidine

Product 1

HCID 574976164-{2-[2-(3-Methoxyphenyl)ethyl]phenoxy}-1-methylpiperidine hydrochlorideYield 69%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

0.2 ml of a 4N solution of hydrogen chloride in dioxane was added dropwise to a solution of 220 mg of 4-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}-1-methylpiperidine [prepared as described in step (a) above] in 20 ml of ethyl acetate, and the mixture was allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 170 mg (yield 69%) of the title compound as colorless crystals, melting at 147°-148° C.

Workup

  1. customto stand at room temperature
  2. customThe crystals which precipitated
  3. filtrationwere collected by filtration
  4. customdried in vacuo

Sources & evidence

ORD record
ord-51893b3c8af04a8986eb1e6f2dbf65ab
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

Loading…