Hydrochloric Acid → HCID 57497620, compound

HRID 743258Notes

Reaction equation

HRID 743258 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]2[CH:26]=[CH:25][CH:24]=[CH:23][C:13]=2[O:14][CH2:15][C@@H:16]2[O:21][CH2:20][CH2:19][N:18]([CH3:22])[CH2:17]2)[CH:7]=[CH:8][CH:9]=1.C(OCC)(=O)C>O1CCOCC1>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:10][CH2:11][C:12]2[CH:26]=[CH:25][CH:24]=[CH:23][C:13]=2[O:14][CH2:15][C@@H:16]2[O:21][CH2:20][CH2:19][N:18]([CH3:22])[CH2:17]2)[CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 54404358HCID 54404358, compound

Product 1

HCID 57497620HCID 57497620, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

0.25 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 310 mg of (R)-2-{2-[2-(3-methoxyphenyl)ethyl]phenoxymethyl}-4-methylmorpholine [prepared as described in step (a) above] in a small amount of ethyl acetate, and the resulting mixture was allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried invacuo, to give 323 mg (yield 94%) of the title compound as colorless needles, melting at 184°-185° C.

Workup

  1. customto stand at room temperature
  2. customThe crystals which precipitated
  3. filtrationwere collected by filtration
  4. customdried invacuo

Sources & evidence

ORD record
ord-f228b6c4187d40abab7597971e8916cf
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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