Hydrochloric Acid → HCID 57497645, compound

HRID 743326Notes

Reaction equation

HRID 743326 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[CH:29]=[CH:28][CH:27]=[CH:26][C:16]=2[O:17][CH2:18][CH2:19][CH:20]2[CH2:24][CH2:23][CH2:22][N:21]2[CH3:25])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[ClH:30]>O1CCOCC1>[ClH:30].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[CH:29]=[CH:28][CH:27]=[CH:26][C:16]=2[O:17][CH2:18][CH2:19][CH:20]2[CH2:24][CH2:23][CH2:22][N:21]2[CH3:25])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10788927HCID 10788927, compound

Product 1

HCID 57497645HCID 57497645, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

1.00 g of 2-(2-{2-[4-(3,5-dimethoxyphenyl)butyl]phenoxy}ethyl)-1-methylpyrrolidine [prepared as described in step (a) above] was dissolved in 10 ml of dioxane, and 0.8 ml of a 4N solution of hydrogen chloride in dioxane was added to the resulting solution. The mixture was stirred and then concentrated by evaporation under reduced pressure. A suitable amount of pentane was added to the concentrate and the mixture was agitated. The upper pentane layer was removed and the resulting oil was dried in vacuo, to give 1.09 g (a quantitative yield) of the title compound, as an oil.

Workup

  1. concentrationconcentrated by evaporation under reduced pressure
  2. additionA suitable amount of pentane was added to the
  3. concentrationconcentrate
  4. stirringthe mixture was agitated
  5. customThe upper pentane layer was removed
  6. customthe resulting oil was dried in vacuo

Sources & evidence

ORD record
ord-9542175053c1402c82836ac4c93de90b
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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