Hydrochloric Acid → HCID 57497647, compound

HRID 743336Notes

Reaction equation

HRID 743336 reaction equation
[CH3:1][N:2]([CH2:4][CH:5]([OH:23])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH3:3].[ClH:24]>C(OCC)(=O)C.O1CCOCC1>[ClH:24].[CH3:1][N:2]([CH2:4][CH:5]([OH:23])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10665509HCID 10665509, compound

Product 1

HCID 57497647HCID 57497647, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

0.30 g of 3-(N,N-dimethylamino)-1-[2-(3-phenylpropyl)phenoxy]-2-propanol [prepared as described in step (b) above] was dissolved in a small amount of ethyl acetate, and 0.48 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution, which was then concentrated by distillation under reduced pressure. Pentane was added to the resulting concentrate, and the mixture was shaken and then concentrated by distillation under reduced pressure. This operation was repeated twice and the resulting oil was then dried in vacuo, to give 0.41 g (a quantitative yield) of the title compound as a colorless oil.

Workup

  1. additionwas added to the solution, which
  2. concentrationwas then concentrated by distillation under reduced pressure
  3. additionPentane was added to the resulting
  4. concentrationconcentrate
  5. concentrationconcentrated by distillation under reduced pressure
  6. customthe resulting oil was then dried in vacuo

Sources & evidence

ORD record
ord-e493e3fed9ce4c99b2e9e48997868b4a
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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