Hydrochloric Acid → HCID 57497648, compound

HRID 743338Notes

Reaction equation

HRID 743338 reaction equation
[CH3:1][N:2]([CH2:4][CH:5]([OH:25])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:3].[ClH:26]>C(OCC)(=O)C.O1CCOCC1>[ClH:26].[CH3:1][N:2]([CH2:4][CH:5]([OH:25])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10667347HCID 10667347, compound

Product 1

HCID 57497648HCID 57497648, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

0.225 g of 3-(N,N-dimethylamino)-1-[2-(5-phenylpentyl)phenoxy]-2-propanol [prepared as described in step (b) above] was dissolved in a small amount of ethyl acetate, and 0.25 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution. The mixture was then concentrated by distillation under reduced pressure. Pentane was added to the resulting concentrate, and the mixture was shaken and then the upper pentane layer was removed. The operation was repeated twice and the resulting oil was dried in vacuo, to give 0.235 g (yield 94%) of the title compound as a colorless oil.

Workup

  1. additionwas added to the solution
  2. concentrationThe mixture was then concentrated by distillation under reduced pressure
  3. additionPentane was added to the resulting
  4. concentrationconcentrate
  5. customthe upper pentane layer was removed
  6. customthe resulting oil was dried in vacuo

Sources & evidence

ORD record
ord-6a0f77d5a8fa4d5f9d027d78187be3a2
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

Loading…