Hydrochloric Acid → HCID 57497649, compound

HRID 743340Notes

Reaction equation

HRID 743340 reaction equation
[CH3:1][N:2]([CH2:4][CH:5]([OH:26])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH3:3].[ClH:27]>C(OCC)(=O)C.O1CCOCC1>[ClH:27].[CH3:1][N:2]([CH2:4][CH:5]([OH:26])[CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10548508HCID 10548508, compound

Product 1

HCID 57497649HCID 57497649, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 312751,4-DioxaneSolvent

Procedure

0.226 g of 3-(N,N-dimethylamino)-1-[2-(6-phenylhexyl)phenoxy]-2-propanol [prepared as described in step (b) above] was dissolved in a small amount of ethyl acetate, and 0.25 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution. The resulting mixture was then concentrated by distillation under reduced pressure. Pentane was added to the resulting concentrate, and the mixture was shaken and then concentrated by distillation under reduced pressure. This operation was repeated twice, and the resulting oil was dried in vacuo, to give 0.237 g (a quantitative yield) of the title compound as a colorless oil.

Workup

  1. additionwas added to the solution
  2. concentrationThe resulting mixture was then concentrated by distillation under reduced pressure
  3. additionPentane was added to the resulting
  4. concentrationconcentrate
  5. concentrationconcentrated by distillation under reduced pressure
  6. customthe resulting oil was dried in vacuo

Sources & evidence

ORD record
ord-5d6db2355b93401f8e2c94c2a5fc41a0
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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