Hydrochloric Acid → HCID 19423839, compound

HRID 743343Notes

Reaction equation

HRID 743343 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[ClH:27]>O1CCOCC1>[ClH:27].[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19423840HCID 19423840, compound

Product 1

HCID 19423839HCID 19423839, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

125 mg of 1-methyl-2-{2-[2-(5-phenylpentyl)phenoxy]ethyl}pyrrolidine [prepared as described in step (a) above] were dissolved in 3 ml of dioxane, and 0.13 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution. The resulting mixture was then shaken and concentrated by distillation under reduced pressure. Pentane was added to the resulting concentrate, and the mixture was agitated and then concentrated by distillation under reduced pressure. This operation was repeated twice, and then he resulting oil was dried in vacuo, to give 0.138 g (a quantitative yield) of the title compound as a colorless oil.

Workup

  1. concentrationconcentrated by distillation under reduced pressure
  2. additionPentane was added to the resulting
  3. concentrationconcentrate
  4. stirringthe mixture was agitated
  5. concentrationconcentrated by distillation under reduced pressure
  6. customhe resulting oil
  7. customwas dried in vacuo

Sources & evidence

ORD record
ord-2a903de0ee60412f8a2cdf28d8454f03
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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