Ethyl 3-(naphthalen-2-yl)propanoate → 2-Naphthalenepropanol

HRID 743394Notes

Reaction equation

HRID 743394 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][CH2:12][C:13](OCC)=[O:14].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][CH2:12][CH2:13][OH:14]

Participants

4

Reactant 2

HCID 14022513Ethyl 3-(naphthalen-2-yl)propanoateHCID 21226445Aluminium lithium hydride

Product 1

HCID 112062322-Naphthalenepropanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in the first part of Preparation 4, the whole of this ethyl 3-(2-naphthyl)propionate was reacted with 668 mg of lithium aluminum hydride in tetrahydrofuran at room temperature for 1.5 hours. At the end of this time, the reaction mixture was worked up and purified as described in the first part of Preparation 4, to give 3.29 g of 3-(2-naphthyl)propanol as a colorless oil.

Workup

  1. customthat described in the first part of Preparation 4
  2. custompurified
  3. customas described in the first part of Preparation 4

Sources & evidence

ORD record
ord-369aca6a51a94293a501737d7028e18b
Source dataset
uspto-grants-1996_09
Patent number
US05556864

Reaction notes

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