Sulfuric acid magnesium salt (1:1) → HCID 70086218, compound

HRID 743479Notes

Reaction equation

HRID 743479 reaction equation
S([O-])([O-])(=O)=O.[Mg+2].[CH3:7][C:8]1([CH2:14][NH2:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH2:9]1.[C:16]([O:20][CH2:21][CH3:22])(=[O:19])[CH:17]=O>C(Cl)Cl>[CH2:21]([O:20][C:16](=[O:19])[CH:17]=[N:15][CH2:14][C:8]1([CH3:7])[CH:9]=[CH:10][CH:11]=[CH:12][CH2:13]1)[CH3:22]

Participants

5

Reactant 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 70211Ethyl oxoacetateHCID 20261165HCID 20261165, compound

Product 1

HCID 70086218HCID 70086218, compoundYield 989.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a suspension of magnesium sulfate (150 g) and 1-methylphenylmethylamine (37.87 g, 32.9 mmol) in methylene chloride was added dropwise a solution of ethyl glyoxylate (33.55 g; 32.9 mmol) in methylene chloride, and the mixture was stirred at room temperature for 2 hours. The mixture was filtered, the filtrate was concentrated in vacuo to afford 67.5 g (quantitative) of N-[(1-methyl)phenylmethyl]imino-acetic acid ethyl ester, as an oil.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-57d7a6dccc0742e1ae685876bb72afb1
Source dataset
uspto-grants-1996_09
Patent number
US05556909

Reaction notes

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