Ammonia → HCID 19424584, compound

HRID 743495Notes

Reaction equation

HRID 743495 reaction equation
I[CH2:2][C:3]([NH:5][CH2:6][C:7]([C:9]1[CH:22]=[CH:21][C:20]2[C:11](=[C:12]3[C:17](=[CH:18][C:19]=2[NH2:23])[CH:16]=[CH:15][CH:14]=[N:13]3)[N:10]=1)=[O:8])=[O:4].[NH3:24]>CN(C)C=O>[NH2:24][CH2:2][C:3]([NH:5][CH2:6][C:7]([C:9]1[CH:22]=[CH:21][C:20]2[C:11](=[C:12]3[C:17](=[CH:18][C:19]=2[NH2:23])[CH:16]=[CH:15][CH:14]=[N:13]3)[N:10]=1)=[O:8])=[O:4]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 67731327HCID 67731327, compound

Product 1

HCID 19424584HCID 19424584, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

(Iodoacetyl-glycyl)-5-amino-1,10-phenanthroline (6) (Preparation 5; 32.3 mg; 77.0 μmol) was dissolved in 2 ml dimethylformamide. Into this solution, was added 10 ml concentrated ammonia. The reaction mixture was stirred for 1 hr. in the dark, and then was evaporated under vacuum. The crude product was purified by preparative thin layer chromatography (silica; 2000 μm; ammonia:95% ethanol, 1:20, v/v). Yield: 10.5 mg, 44%.

Workup

  1. customin the dark, and then was evaporated under vacuum
  2. customThe crude product was purified by preparative thin layer chromatography (silica

Sources & evidence

ORD record
ord-108ad69423094f19a9b2db869bf2bb3e
Source dataset
uspto-grants-1996_09
Patent number
US05556949

Reaction notes

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