Methylamine → 1-(Diphenylmethyl)-N-methylazetidin-3-amine

HRID 743663Notes

Reaction equation

HRID 743663 reaction equation
[CH:1]([N:14]1[CH2:17][CH:16](OS(C)(=O)=O)[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23][NH2:24]>CO>[CH:1]([N:14]1[CH2:17][CH:16]([NH:24][CH3:23])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 27587161-(Diphenylmethyl)azetidin-3-yl methanesulfonate

Product 1

HCID 503191-(Diphenylmethyl)-N-methylazetidin-3-amineYield 67.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-Benzhydryl-3-(methylamino)azetidine was prepared under the conditions of Example 9, but starting with 50 g of 1-benzhydryl-3-(methanesulphonyloxy)-azetidine and 48.9 g of methylamine in 250 cm3 of methanol. 27 g of 1-benzhydryl-3-(methylamino)azetidine are obtained in the form of a colorless solid, melting point 75° C.

Workup

  1. custom1-Benzhydryl-3-(methylamino)azetidine was prepared under the conditions of Example 9

Sources & evidence

ORD record
ord-a5d9d18420604078a9804d62c30246f3
Source dataset
uspto-grants-1996_09
Patent number
US05556861

Reaction notes

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