反应详情

温度

40 °C

2.62 g (8.05 mmol) of 4,4-dimethyl-2-(4'-methoxymethoxymethylbiphenyl-2-yl)oxazoline was dissolved in methanol (20 ml). 6N hydrochloric acid (10 ml) was added thereto, followed by stirring at 40° C. for 2 hours. The reaction liquid was poured into a saturated aqueous solution of sodium hydrogen-carbonate, followed by the extraction with chloroform. After washing with water and drying, vacuum concentration was conducted. The residue was purified by silica gel column chromatography (a n-hexane/ethyl acetate system) to give 2.20 g of the title compound as a crystal (yield 97%). m.p.; 97°-100° C.

1. customThe reaction liquid
2. extractionfollowed by the extraction with chloroform
3. washAfter washing with water
4. customdrying
5. concentrationvacuum concentration
6. customThe residue was purified by silica gel column chromatography (a n-hexane/ethyl acetate system)